To examine the recent, most relevant genetic and epigenetic modifications of the epithelial barrier in response to the environmental factors, including allergens, viruses, and pollutants, susceptible to participate to asthma.
IL-33 and TSLP gene polymorphisms are found in almost all asthma studies. Recent data have highlighted a new population of innate lymphoid cells, activated by these two cytokines, and mediating type 2 innate immunity dependent asthma. Gene variants of innate pattern recognition receptors associated with asthma have been evidenced in early viral infected high-risk birth cohorts, as well as polymorphisms in pathways involved in type I interferon (IFN) production, giving further insight into the role of viruses in asthma development. Novel epigenetic mechanisms have been evidenced in asthma and in response to the environmental pollutants, and point out genes like TSLP, which may link environmental pollution and asthma.
Genetic data support the role of a specific set of epithelial-derived proTh2 cytokines, including IL-33 and TSLP, as well as the role of decreased type I IFN in virus-induced impaired epithelial barrier. Epigenetic modifications of epithelial genes are promising mechanisms that warrant further investigation.
aPulmonary Immunity, Institut National de la Santé Et de la Recherche Médicale, U1019
bInstitut Pasteur de Lille, Center for Infection and Immunity of Lille
cCNRS UMR 8204
dUniv Lille Nord de France, Lille, France
Correspondence to Anne Tsicopoulos, Pulmonary Immunity, Center for Infection and Immunity of Lille, Institut Pasteur de Lille, 1 rue du Prof Calmette, BP 245, 59019 Lille, France. Tel: +33 320 877 221; fax: +33 320 877 345; e-mail: email@example.com