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Treatment of food anaphylaxis with traditional Chinese herbal remedies: from mouse model to human clinical trials

Wang, Julie

Current Opinion in Allergy & Clinical Immunology: August 2013 - Volume 13 - Issue 4 - p 386–391
doi: 10.1097/ACI.0b013e3283615bc4
ANAPHYLAXIS AND INSECT ALLERGY: Edited by Theodore Freeman and Ralf Heine

Purpose of review: To describe the development of a novel treatment for food allergy, named the food allergy herbal formula-2 (FAHF-2), that is based on traditional Chinese medicine.

Recent findings: FAHF-2 has proven to be well tolerated and effective for the treatment of food allergies in murine models of peanut and multiple food allergies. These results are accompanied by evidence of favorable immune modulation, and the effects are persistent after the discontinuation of treatment. Early clinical trials demonstrate the safety and tolerability of this formula in individuals with food allergies. An ongoing Phase II clinical trial will evaluate the efficacy of FAHF-2 in protecting individuals from allergen-induced allergic reactions during oral food challenges.

Summary: FAHF-2 is an herbal formula that has a high safety profile and has shown to prevent anaphylaxis in murine models of food allergy. Similar findings in clinical trials could bring a novel treatment for food allergies.

Division of Allergy and Immunology, Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, New York, USA

Correspondence to Julie Wang, MD, Department of Pediatrics, Box 1198, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029-6574, USA. Tel: +1 212 241 5548; fax: +1 212 426 1902; e-mail: Julie.wang@mssm.edu

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