Skip Navigation LinksHome > August 2013 - Volume 13 - Issue 4 > Component-resolved diagnosis in pediatric allergic rhinoconj...
Current Opinion in Allergy & Clinical Immunology:
doi: 10.1097/ACI.0b013e32836274d8
Special Commentary

Component-resolved diagnosis in pediatric allergic rhinoconjunctivitis and asthma

Melioli, Giovannia; Passalacqua, Giovannib; Canonica, Giorgio Walterb; Baena-Cagnani, Carlos E.c; Matricardi, Paolod

Collapse Box


Purpose of review: The aim of this review is to update readers on the growing impact of a molecular approach (CRD) to the diagnosis and treatment of children with respiratory allergies

Recent findings: A large panel of highly purified natural or recombinant species-specific and cross-reacting allergenic molecules is now available for clinical purposes. Species-specific molecules allow identifying specific sensitization toward a given allergenic source. Cross-reacting molecules allow interpreting polysensitization patterns that cannot be detailed using routine skin prick tests or specific IgE tests based on allergenic extracts. These molecular tools are transforming and improving the interpretation of clinical and laboratory tests used to define patients’ IgE-sensitization profile.

Summary: The accurate dissection of the IgE repertoire offers new possibilities in the diagnosis, prophylaxis and treatment of pediatric allergic rhinoconjunctivitis and asthma.

© 2013 by Lippincott Williams & Wilkins, Inc.


Article Tools


Article Level Metrics

Search for Similar Articles
You may search for similar articles that contain these same keywords or you may modify the keyword list to augment your search.