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Food allergy: the perspectives of prevention using vitamin D

Peroni, Diego G.; Boner, Attilio L.

Current Opinion in Allergy & Clinical Immunology:
doi: 10.1097/ACI.0b013e328360ed9c
FOOD ALLERGY: Edited by Alessandro Fiocchi and Julie Wang

Purpose of review: We reviewed the scientific publications in the last 2 years on the connections between vitamin D and food allergy, and endeavor to focus on the possible indications for supplementation in order to prevent allergies.

Recent findings: Ecological studies have suggested a possible relationship between sun exposure and atopic diseases such as asthma, atopic dermatitis and anaphylaxis. However, no direct evaluation of vitamin D status has been performed. Recent studies evaluating the relationship with vitamin D levels at birth or during pregnancy have shown conflicting results with the lower levels of vitamin D associated with eczema, the higher with increased food allergy prevalence.

Summary: Although the role of vitamin D in extraskeletal function is certainly intriguing and must not be underestimated, at the moment there is a lack of consistent data addressing the topic of vitamin D supplementation in the prevention of food allergies. However, in light of the vast amount of literature regarding the mechanisms connected with atopic diseases, an evaluation of serum levels of vitamin D and eventually supplementation must be considered as a further opportunity to understand and treat atopic diseases. In this regard, well designed trials on vitamin D supplementation to prevent food allergies are urgently needed.

Author Information

Pediatric Department, University of Verona Hospital, Verona, Italy

Correspondence to Professor Diego G. Peroni, Pediatric Department, Ospedale G.B.Rossi, 37134 Verona, Italy. Tel: +39 45 8126884; fax: +39 45 8124790; e-mail:

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