Skip Navigation LinksHome > October 2012 - Volume 12 - Issue 5 > The role of interleukin-1 in allergy-related disorders
Current Opinion in Allergy & Clinical Immunology:
doi: 10.1097/ACI.0b013e3283574d0c
SKIN ALLERGY: Edited by Thomas Werfel and Torsten Zuberbier

The role of interleukin-1 in allergy-related disorders

Krause, Karolinea,b; Metz, Martina,b; Makris, Michaelb,c; Zuberbier, Torstena,b; Maurer, Marcusa,b

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Abstract

Purpose of review: Interleukin-1β (IL-1β) is a potent proinflammatory cytokine, which is involved in many inflammatory conditions including autoinflammatory and allergic disorders. This review provides insights into recent advances of our understanding of the pathogenesis of IL-1β-associated allergy-related disorders.

Recent findings: In autoinflammatory as well as allergic diseases such as contact hypersensitivity, atopic dermatitis and bronchial asthma, dysfunctional inflammasome processing has been demonstrated to account for IL-1β-induced inflammation. IL-1-neutralizing drugs have been shown to completely suppress or markedly reduce inflammatory responses in clinical studies and experimental models of urticarial autoinflammatory diseases as well as common allergic disorders.

Summary: The recent findings support a crucial role for IL-1β and inflammasome components in a variety of allergy-related disorders.

© 2012 Lippincott Williams & Wilkins, Inc.

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