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The role of interleukin-1 in allergy-related disorders

Krause, Karoline; Metz, Martin; Makris, Michael; Zuberbier, Torsten; Maurer, Marcus

Current Opinion in Allergy and Clinical Immunology: October 2012 - Volume 12 - Issue 5 - p 477–484
doi: 10.1097/ACI.0b013e3283574d0c
SKIN ALLERGY: Edited by Thomas Werfel and Torsten Zuberbier

Purpose of review Interleukin-1β (IL-1β) is a potent proinflammatory cytokine, which is involved in many inflammatory conditions including autoinflammatory and allergic disorders. This review provides insights into recent advances of our understanding of the pathogenesis of IL-1β-associated allergy-related disorders.

Recent findings In autoinflammatory as well as allergic diseases such as contact hypersensitivity, atopic dermatitis and bronchial asthma, dysfunctional inflammasome processing has been demonstrated to account for IL-1β-induced inflammation. IL-1-neutralizing drugs have been shown to completely suppress or markedly reduce inflammatory responses in clinical studies and experimental models of urticarial autoinflammatory diseases as well as common allergic disorders.

Summary The recent findings support a crucial role for IL-1β and inflammasome components in a variety of allergy-related disorders.

aAutoinflammation Reference Center Charité, Charité - Universitätsmedizin Berlin

bDepartment of Dermatology and Allergy, Charité-Universitätsmedizin Berlin, Berlin, Germany

c2nd Department of Dermatology and Venereology, Medical School, University of Athens, Attikon University Hospital, Athens, Greece

Correspondence to Karoline Krause, MD, Department. of Dermatology and Allergy, Charitéplatz 1, 10117 Berlin, Germany. Tel: +49 30 45 051 8336; e-mail: Karoline.krause@charite.de

Copyright © 2012 Wolters Kluwer Health, Inc. All rights reserved.