Skip Navigation LinksHome > October 2012 - Volume 12 - Issue 5 > The role of interleukin-1 in allergy-related disorders
Current Opinion in Allergy & Clinical Immunology:
doi: 10.1097/ACI.0b013e3283574d0c
SKIN ALLERGY: Edited by Thomas Werfel and Torsten Zuberbier

The role of interleukin-1 in allergy-related disorders

Krause, Karoline; Metz, Martin; Makris, Michael; Zuberbier, Torsten; Maurer, Marcus

Collapse Box

Abstract

Purpose of review: Interleukin-1β (IL-1β) is a potent proinflammatory cytokine, which is involved in many inflammatory conditions including autoinflammatory and allergic disorders. This review provides insights into recent advances of our understanding of the pathogenesis of IL-1β-associated allergy-related disorders.

Recent findings: In autoinflammatory as well as allergic diseases such as contact hypersensitivity, atopic dermatitis and bronchial asthma, dysfunctional inflammasome processing has been demonstrated to account for IL-1β-induced inflammation. IL-1-neutralizing drugs have been shown to completely suppress or markedly reduce inflammatory responses in clinical studies and experimental models of urticarial autoinflammatory diseases as well as common allergic disorders.

Summary: The recent findings support a crucial role for IL-1β and inflammasome components in a variety of allergy-related disorders.

Copyright © 2012 Wolters Kluwer Health, Inc. All rights reserved.

Login

Article Tools

Share

Article Level Metrics

Search for Similar Articles
You may search for similar articles that contain these same keywords or you may modify the keyword list to augment your search.