Skip Navigation LinksHome > June 2012 - Volume 12 - Issue 3 > Vitamin D and atopy and asthma phenotypes in children
Current Opinion in Allergy & Clinical Immunology:
doi: 10.1097/ACI.0b013e3283534a32
OUTCOME MEASURES: Edited by Henry Milgrom and Ralph Mosges

Vitamin D and atopy and asthma phenotypes in children

Hollams, Elysia M.

Collapse Box


Purpose of review: To give an overview of the recent research into whether a lack of vitamin D contributes to the development of atopy and asthma in childhood.

Recent findings: I describe here the recent epidemiological studies relating vitamin D status to atopy and asthma in children, focusing on determinants of major asthma phenotypes in childhood. Recent findings include the observations that vitamin D levels are inversely associated with degree of corticosteroid use, worsening airflow limitation and increased exacerbations among asthmatics. Low vitamin D has been associated with atopy and asthma in children and adolescents in a community cohort, predominantly in boys, with vitamin D at age 6 predicting these outcomes at 14. I also detail the mechanistic studies examining relevant vitamin D-regulated processes; recent findings include the demonstration that offspring of mice with vitamin D deficiency in pregnancy show reduced lung volume and function.

Summary: The current literature suggests that intervention to ensure adequate vitamin D levels during both pregnancy and childhood may reduce the development of atopy and asthma in children. However, important questions need to be answered regarding the levels of vitamin D required, which may vary between the sexes and between individuals, and the optimal timing and duration of such intervention.

Copyright © 2012 Wolters Kluwer Health, Inc. All rights reserved.


Article Tools


Article Level Metrics

Search for Similar Articles
You may search for similar articles that contain these same keywords or you may modify the keyword list to augment your search.