Skip Navigation LinksHome > June 2012 - Volume 12 - Issue 3 > Oral immunotherapy for cow's milk allergy
Current Opinion in Allergy & Clinical Immunology:
doi: 10.1097/ACI.0b013e3283535b93
FOOD ALLERGY: Edited by Alessandro Fiocchi and Julie Wang

Oral immunotherapy for cow's milk allergy

Passalacqua, Giovanni; Landi, Massimo; Pajno, Giovanni B.

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Purpose of review: Cow's milk allergy (CMA) is common in children and may lead to severe systemic reactions. Avoidance of the ingestion of cow milk is the only effective approach, but this does not exclude the inadvertent or accidental ingestion, or the assumption of milk hidden in other foods. As no pharmacological treatment is available, specific desensitization has been considered an attractive strategy.

Recent findings: In the last years, several trials of oral desensitization to cow milk, with different protocols, were published. Overall the results were favourable and demonstrated the achievement of a full tolerance in a high percentage of children. Mild side effects that can be easily managed by slowing the desensitization were reported frequently. The discontinuation of the procedure was necessary in less than 20% of children, on average, due to severe side effects.

Summary: Oral immunotherapy (oral desensitization) seems to be a promising treatment strategy for cow milk allergy in children that can be applied also to other foods such as eggs or peanuts.

Copyright © 2012 Wolters Kluwer Health, Inc. All rights reserved.


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