You could be reading the full-text of this article now if you...

If you have access to this article through your institution,
you can view this article in

Food allergy guidelines and assessing allergic reaction risks: a regulatory perspective

Luccioli, Stefano

Current Opinion in Allergy & Clinical Immunology:
doi: 10.1097/ACI.0b013e3283535aaf
FOOD ALLERGY: Edited by Alessandro Fiocchi and Julie Wang
Abstract

Purpose of review: To review information in food allergy guidelines and the literature on assessing and understanding food allergic reaction risks.

Recent findings: Current food allergy guidelines have focused on tools for better diagnosis of food allergy and treatment of reactions. These guidelines have not addressed the growing body of literature on risk assessment and diagnostic tools being used to assess dose–response relationships in relation to food-allergen exposures. The literature includes substantial data from food-allergen challenges performed in sensitive individuals, and probabilistic modeling of these data may help to elucidate the relationship between allergen dose exposures, including thresholds, and reaction risk in allergic individuals. Understanding this relationship has potential to improve the health-related quality of life of allergic consumers.

Summary: Recent findings in the literature have highlighted improved diagnostic tools and other information that can be used to assess risks for allergic reaction to low-dose allergen exposures (thresholds) and reaction severity in food allergic consumers. Recommendations to better define and stratify allergic reaction risks for consumers could be adopted into guidelines for the diagnosis and clinical management of food allergy.

Author Information

Office of Food Additive Safety, Center for Food Safety and Applied Nutrition, United States Food and Drug Administration, College Park, Maryland, USA

Correspondence to Stefano Luccioli, MD, Office of Food Additive Safety, Center for Food Safety and Applied Nutrition, United States Food and Drug Administration, 5100 Paint Branch Parkway, HFS-200, College Park, MD 20740, USA. E-mail: Stefano.Luccioli@fda.hhs.gov

Copyright © 2012 Wolters Kluwer Health, Inc. All rights reserved.