Skip Navigation LinksHome > June 2012 - Volume 12 - Issue 3 > Egg oral immunotherapy
Current Opinion in Allergy & Clinical Immunology:
doi: 10.1097/ACI.0b013e3283535bae
FOOD ALLERGY: Edited by Alessandro Fiocchi and Julie Wang

Egg oral immunotherapy

Vickery, Brian P.

Collapse Box

Abstract

Purpose of review: Egg allergy is one of the most common food allergies of childhood and no interventional therapy is currently approved by the Food and Drug Administration. Much recent research has focused on the safety, efficacy, and mechanism of oral immunotherapy (OIT) as a disease-modifying treatment.

Recent findings: Small pilot studies with varying protocol designs have shown egg OIT to be relatively well tolerated, and efficacy is suggested but not formally demonstrated. At this time, no placebo-controlled randomized trial has been published confirming desensitization and no published study has convincingly demonstrated the development of OIT-induced tolerance to egg.

Summary: Egg OIT is a promising modality for providing temporary protection from reactions caused by accidental egg exposure. However, the overall strength of the evidence in favor of egg OIT is limited by small sample sizes and the lack of controls, both of which are important considerations given the spontaneous resolution expected in egg allergy. More high-quality studies are necessary before egg OIT can be recommended as a viable treatment option.

© 2012 Lippincott Williams & Wilkins, Inc.

Login

Search for Similar Articles
You may search for similar articles that contain these same keywords or you may modify the keyword list to augment your search.