Skip Navigation LinksHome > February 2012 - Volume 12 - Issue 1 > T-cell responses during allergen-specific immunotherapy
Current Opinion in Allergy & Clinical Immunology:
doi: 10.1097/ACI.0b013e32834ecc9a
RHINITIS, SINUSITIS AND UPPER AIRWAY DISEASE: Edited by Ruby Pawankar and David P. Skoner

T-cell responses during allergen-specific immunotherapy

Maggi, Enrico; Vultaggio, Alessandra; Matucci, Andrea

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Abstract

Purpose of review: Allergen-specific immunotherapy is the only specific, dose-dependent and time-dependent and disease-modifying strategy for the treatment of allergy associated with clinical improvement and biological tolerance which may persist years after discontinuation.

Recent findings: Successful immunotherapy in respiratory allergy is associated with the immunodeviation of Th2 response to a more protective allergen-specific Th1 cells and with the induction of interleukin-10 (IL-10)/transforming growth factor (TGF)-β-producing T regulatory cells in blood and inflamed airways. Subcutaneous treatment and sublingual treatments induce similar alterations which are dose-dependent and time-dependent.

Summary: This study provides an update on the immunological T-cell responses during subcutanous immunotherapy and sublingual immunotherapy, giving a unifying view of the redirecting mechanisms and regulating mechanisms elicited by these treatments.

Copyright © 2012 Wolters Kluwer Health, Inc. All rights reserved.

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