Skip Navigation LinksHome > February 2012 - Volume 12 - Issue 1 > T-cell responses during allergen-specific immunotherapy
Current Opinion in Allergy & Clinical Immunology:
doi: 10.1097/ACI.0b013e32834ecc9a
RHINITIS, SINUSITIS AND UPPER AIRWAY DISEASE: Edited by Ruby Pawankar and David P. Skoner

T-cell responses during allergen-specific immunotherapy

Maggi, Enrico; Vultaggio, Alessandra; Matucci, Andrea

Collapse Box


Purpose of review: Allergen-specific immunotherapy is the only specific, dose-dependent and time-dependent and disease-modifying strategy for the treatment of allergy associated with clinical improvement and biological tolerance which may persist years after discontinuation.

Recent findings: Successful immunotherapy in respiratory allergy is associated with the immunodeviation of Th2 response to a more protective allergen-specific Th1 cells and with the induction of interleukin-10 (IL-10)/transforming growth factor (TGF)-β-producing T regulatory cells in blood and inflamed airways. Subcutaneous treatment and sublingual treatments induce similar alterations which are dose-dependent and time-dependent.

Summary: This study provides an update on the immunological T-cell responses during subcutanous immunotherapy and sublingual immunotherapy, giving a unifying view of the redirecting mechanisms and regulating mechanisms elicited by these treatments.

Copyright © 2012 Wolters Kluwer Health, Inc. All rights reserved.


Article Tools


Article Level Metrics

Search for Similar Articles
You may search for similar articles that contain these same keywords or you may modify the keyword list to augment your search.