Pathophysiology of anaphylaxisKhan, Bilal Q.; Kemp, Stephen F.Current Opinion in Allergy and Clinical Immunology: August 2011 - Volume 11 - Issue 4 - p 319–325 doi: 10.1097/ACI.0b013e3283481ab6 Anaphylaxis and insect allergy: Edited by Theodore Freeman and Ralf G. Heine Abstract Author Information Purpose of review This review aims to provide an overview of the evolving understanding of the pathophysiology of anaphylaxis. Recent findings Immunopathologic mechanisms of anaphylaxis have traditionally focused on the IgE-dependent and IgE-independent release of mediators from mast cells and basophils. There are accumulating data supporting the significance of alternative pathways of anaphylaxis. Increasing attention has also focused on the internal compensatory mechanisms activated in response to anaphylaxis. Summary Recent advances will enhance understanding of the pathophysiology of anaphylaxis and might have future implications for diagnosis and management. Division of Clinical Immunology and Allergy, Departments of Medicine and Pediatrics, The University of Mississippi Medical Center, Jackson, Mississippi, USA Correspondence to Stephen F. Kemp, MD, Division of Clinical Immunology and Allergy, Departments of Medicine and Pediatrics, The University of Mississippi Medical Center, 768 Lakeland Drive, LJ Bldg., Jackson, MS 39216, USA Tel: +1 601 815 1058; e-mail: firstname.lastname@example.org Copyright © 2011 Wolters Kluwer Health, Inc. All rights reserved.