Skip Navigation LinksHome > April 2011 - Volume 11 - Issue 2 > The indoor environment and its effects on childhood asthma
Current Opinion in Allergy & Clinical Immunology:
doi: 10.1097/ACI.0b013e3283445921
Pediatric asthma and development of atopy: Edited by Carlos E. Baena-Cagnani and Leonard B. Bacharier

The indoor environment and its effects on childhood asthma

Ahluwalia, Sharon K; Matsui, Elizabeth C

Collapse Box

Abstract

Purpose of review: Indoor pollutants and allergens cause asthma symptoms and exacerbations and influence the risk of developing asthma. We review recent studies regarding the effects of the indoor environment on childhood asthma.

Recent findings: Exposure to some indoor allergens and second hand smoke are causally related to the development of asthma in children. Many recent studies have demonstrated an association between exposure to indoor pollutants and allergens and airways inflammation, asthma symptoms, and increased healthcare utilization among individuals with established asthma. Genetic polymorphisms conferring susceptibility to some indoor exposures have also been identified, and recent findings support the notion that environmental exposures may influence gene expression through epigenetic modification. Recent studies also support the efficacy of multifaceted environmental interventions in childhood asthma.

Summary: Studies have provided significant evidence of the association between many indoor pollutants and allergens and asthma morbidity, and have also demonstrated the efficacy of multifaceted indoor environmental interventions in childhood asthma. There is also a growing body of evidence suggesting that some indoor pollutants and allergens may increase the risk of developing asthma. Future studies should examine mechanisms whereby environmental exposures may influence asthma pathogenesis and expand the current knowledge of susceptibility factors for indoor exposures.

© 2011 Lippincott Williams & Wilkins, Inc.

Login

Search for Similar Articles
You may search for similar articles that contain these same keywords or you may modify the keyword list to augment your search.