Synopsis: In a multicenter trial, monotherapy with meropenem was as good as combination therapy with meropenem and ciprofloxacin for ventilator-associated pneumonia (VAP) in patients at low risk for multidrug resistant organisms.
Source: Heyland DK, Dodek P, Muscedere J, et al. Randomized trial of combination versus monotherapy for the empiric treatment of suspected ventilator-associated pneumonia. Crit Care Med. 2008;36:737-744.