Synopsis: Empiric antibiotics are frequently used in the intensive care unit (ICU) in the absence of confirmed infections and, in these cases, prolonged use is not helpful and may be harmful.
Source: Aarts MAW, Brun-Buisson C, Cool DJ, et al. Antibiotic management of suspected nosocomial ICU-acquired infection: does prolonged empiric therapy improve outcome? Intensive Care Med. 2007;33:1369-1378.