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Diagnostic Utility of Transbronchial Cryobiopsy in Interstitial Lung Disease

Sharma, Deepankar MD; Loh, Chee Hong MD; Bellinger, Christina R. MD

doi: 10.1097/CPM.0000000000000198
Interstitial, Inflammatory, Occupational Lung Disease/Interventional Pulmonary Medicine

Interstitial lung disease is a heterogenous group of disorders characterized by varying patterns of inflammation and fibrosis. Its diagnosis requires a multidisciplinary approach including clinical and imaging correlation, but atypical presentations and imaging warrant tissue biopsy. Transbronchial forceps biopsy has a low yield and is not recommended for diagnosis. Although considered as the gold standard, surgical lung biopsy is associated with significant morbidity and mortality. Transbronchial cryobiopsy is a relatively newer technique, but only limited data are available to establish its utility in diagnosing interstitial lung disease and evaluating the associated risks to this procedure.

Department of Internal Medicine, Division of Pulmonary, Critical Care, Allergy, and Immunologic Disease, Wake Forest School of Medicine, Winston Salem, NC

Disclosure: The authors declare that they have no conflicts of interest.

Address correspondence to: Deepankar Sharma, MD, Department of Internal Medicine, Division of Pulmonary, Critical Care, Allergy, and Immunologic Disease, Wake Forest School of Medicine, Medical Center Blvd, Winston Salem, NC 27157. E-mail: ds.ip@hotmail.com.

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