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Extracapillary IgA Nephropathy and Pulmonary Tuberculosis

Fofi, Claudia MD, PhD; Cherubini, Chiara MD; Barbera, Giovanni MD; Nicoletti, Maria Concetta Domenica MD; Di Giulio, Salvatore MD

Clinical Pulmonary Medicine:
Colleagues in Respiratory Medicine
Abstract

The association of tuberculosis with IgA Nephropathy (IgAN) is an uncommon occurrence. IgAN may be a consequence of tuberculosis, possibly because of an abnormal IgA-mediated immune response against Mycobacterium Tuberculosis. In subjects with acute nephritis during tuberculosis infection, it remains difficult to formulate a differential diagnosis among primary or secondary renal involvement because of tuberculosis itself or to antituberculous agents. Moreover, glomerulonephritides occurring during infectious diseases always represent a difficult condition to define the appropriate pharmacological treatment, considering the high risks of immunosuppression, which need to be evaluated in the single patient. We describe a 75-year-old male patient with acute renal insufficiency secondary to extracapillary IgA nephropathy during recently diagnosed pulmonary tuberculosis. The possible role of tuberculosis and antituberculous medication in the pathogenesis of renal involvement is discussed, with a review of the pertinent literature.

In Brief

This manuscript describes the occurrence of extracapillary IgA nephropathy and pulmonary tuberculosis. The association of tuberculosis with IgA nephropathy is an uncommon event. The authors discuss the possible role of tuberculosis and antituberculous medication in the pathogenesis of renal involvement, with a review of the pertinent literature.

Author Information

From the Nephrology and Dialysis Unit, S. Camillo-Forlanini Hospital, Piazza Carlo Forlanini 1, Rome, Italy.

Address for correspondence: Dr. Claudia Fofi, Borgo Pio 150, 00193 Rome, Italy. E-mail: clafofi@tiscali.it.

© 2005 Lippincott Williams & Wilkins, Inc.