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Clinical Journal of Pain:
doi: 10.1097/AJP.0000000000000082
Original Article: PDF Only

Real-World Experience with Once-Daily Gabapentin for the Treatment of Postherpetic Neuralgia (PHN).

Markley, Herbert G. MD; Dunteman, Edwin D. MD; Sweeney, Michael MD

Open Access
Published Ahead-of-Print
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Objectives: To evaluate the safety and effectiveness of once-daily gastroretentive gabapentin (G-GR) for treatment of PHN in real-world clinical practice.

Methods: Patients aged >=18 years were divided into 2 cohorts: patients <=70 years and patients >70 years. All patients were titrated to 1800 mg G-GR/d over 2 weeks and maintained at that dosage for 6 weeks, for 8 weeks total treatment. To reflect clinical practice, exclusion criteria were limited to those in the product label. Efficacy was assessed using a visual analog scale (VAS) and the Brief Pain Inventory (BPI). Patient/Clinician Global Impression of Change (PGIC/CGIC) scales were completed at Week 8. Adverse events (AEs) were assessed.

Results: The efficacy population included 190 patients (110, <=70 y; 80, >70 y). The mean percent change in VAS score at Week 8 from baseline was -21.3%/-20.4% (<=70 y/>70 y). The proportion of patients with a >=30% reduction in VAS score from baseline was 51.8%/55.0% (<=70 y/>70 y) and was 42.7%/37.5% for a >=50% reduction. BPI scores were all significantly reduced by Week 8. On the PGIC instrument, more patients <=70 years reported feeling "Much" or "Very much" improved from baseline (59.0% vs. 40.3%). G-GR was generally well tolerated. Thirty-seven (18.8%) patients experienced AEs that led to discontinuation. No patients died and 5 (2.5%) patients experienced serious AEs. The most common G-GR-related AEs (<=70 y/>70 y) were dizziness (11.7%/16.3%) and somnolence (3.6%/8.1%).

Discussion: In real-world clinical practice, G-GR appears to be an effective, well-tolerated treatment option for patients with PHN, regardless of age.

This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivitives 3.0 License, where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially.

(C) 2014 by Lippincott Williams & Wilkins

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