Skip Navigation LinksHome > Published Ahead-of-Print > Ability of the Central Sensitization Inventory to Identify C...
Clinical Journal of Pain:
doi: 10.1097/AJP.0000000000000113
Original Article: PDF Only

Ability of the Central Sensitization Inventory to Identify Central Sensitivity Syndromes in an Outpatient Chronic Pain Sample.

Neblett, Randy MA, LPC, BCB; Hartzell, Meredith M. MS, PhD Candidate; Cohen, Howard MD; Mayer, Tom G. MD; Williams, Mark PhD; Choi, YunHee MA, PhD; Gatchel, Robert J. PhD, ABPP

Published Ahead-of-Print
Collapse Box


Objectives: To determine the ability of the Central Sensitization Inventory (CSI), a new screening instrument, to assist clinicians in identifying patients with Central Sensitivity Syndromes (CSSs).

Methods: Patients from a psychiatric medical practice (N=161), which specialized in the assessment and treatment of complex pain and psychophysiological disorders, were assessed for the presence of a CSS. CSI scores, using a previously determined cutoff of "40" out of "100," were compared between the CSS patient group (n=99) and the non-CSS patient group (n=62). Information on false positives, false negatives, true positives, and true negatives were analyzed, and sensitivity and specificity analyses were conducted. Additionally, CSS-relevant variables such as depression, abuse, and substance abuse were examined.

Results: A large percentage of CSS patients had comorbid major depressive disorder (80%) and abuse history (43%), which was higher than rates for the patients without a CSS (55% and 24%, respectively). The CSI correctly identified 82.8% (n=82) of CSS patients as having a CSS (i.e., sensitivity) and 54.8% (n=28) of non-CSS patients as not having a CSS (i.e., specificity). False-positive patients (not diagnosed with a CSS, but scoring greater than 40 on the CSI) reported more severe pain, interference in daily functioning, and abuse history, compared to the non-CSS patients who scored below 40 (i.e., true negatives).

Conclusions: The CSI is a useful and valid instrument for screening patients for the possibility of a CSS, although the chances of false-positives are relatively high when evaluating patients with complex pain and psychophysiological disorders.

(C) 2014 Wolters Kluwer Health, Inc. All rights reserved.

Search for Similar Articles
You may search for similar articles that contain these same keywords or you may modify the keyword list to augment your search.