Institutional members access full text with Ovid®

Share this article on:

Mindfulness-Based Intervention Does Not Influence Cardiac Autonomic Control or the Pattern of Physical Activity in Fibromyalgia During Daily Life: An Ambulatory, Multimeasure Randomized Controlled Trial

Grossman, Paul PhD; Deuring, Gunnar MS; Walach, Harald PhD; Schwarzer, Barbara MD; Schmidt, Stefan PhD

The Clinical Journal of Pain: May 2017 - Volume 33 - Issue 5 - p 385–394
doi: 10.1097/AJP.0000000000000420
Original Articles

Objectives: Fibromyalgia (FM) is a syndrome characterized by severe pain, fatigue and sleep disturbance. There is evidence of central hyper-responsiveness to sensory stimulation and impaired cardiovascular autonomic control. Laboratory investigations suggest that mindfulness-based stress reduction (MBSR) may improve autonomic functioning in FM. However, these findings may not reflect what occurs during naturalistic conditions, and MBSR studies during real-life functioning are lacking. We conducted a randomized controlled, 3-armed study with 168 female FM patients. This report describes cardiac, respiratory, and physical activity findings.

Methods: Eight-week MBSR was compared with wait-list and active control intervention. Ambulatory accelerometry and cardiorespiratory function were monitored over 24-h periods at 3 time points: preintervention, postintervention, and at the 8-week follow-up. Also, baseline levels were compared with an age-matched group of 33 healthy women.

Findings: Activity heart rate, respiratory sinus arrhythmia, and ventilation were measured. Comparison with controls confirmed differences in cardiac autonomic tone and activity pattern among patients. Most measures also showed effects of time of day and point of measurement. Regarding the intervention study, there were no effects of treatment. In addition, there were no relations between patient-reported clinical improvement and objective physiological or accelerometry parameters. Intervention-related benefits in wellbeing were not associated with changes in daytime cardiorespiratory measures or pattern of physical activity.

Conclusions: MBSR did not produce cardiac autonomic benefits or changes in daily activity in FM. Furthermore, the lack of an association between patient-experienced clinical improvement and objective physiological measures suggests that subjective changes in the wellbeing of FM patients over time are not related to alterations in the cardiorespiratory autonomic function or activity levels.

*Department of Psychosomatic Medicine, Division of Internal Medicine, University Hospital Basel, Basel, Switzerland

Brain, Mind and Healing Program, Samueli Institute, Alexandria, VA

Institute of Transcultural Health Studies, European University Viadrina, Frankfurt (Oder)

§Institute of Environmental Health Sciences

Department of Psychosomatic Medicine and Psychotherapy, Medical Faculty, Medical Center – University of Freiburg, Freiburg, Germany

ClinicalTrials.gov Identifier: NCT00106275.

Supported by the Samueli Institute, Alexandria, VA. The authors declare no conflict of interest.

Reprints: Paul Grossman, PhD, Department of Psychosomatic Medicine, University Hospital Basel, Hebelstrasse 2, Basel CH-4031, Switzerland (e-mail: paul.grossman@usb.ch).

Received February 22, 2016

Received in revised form November 9, 2016

Accepted July 16, 2016

Copyright © 2017 Wolters Kluwer Health, Inc. All rights reserved.