Skip Navigation LinksHome > July 2014 - Volume 30 - Issue 7 > Co-bedding Between Preterm Twins Attenuates Stress Response...
Clinical Journal of Pain:
doi: 10.1097/AJP.0000000000000015
Original Articles

Co-bedding Between Preterm Twins Attenuates Stress Response After Heel Lance: Results of a Randomized Trial

Campbell-Yeo, Marsha L. PhD, RN*,†; Johnston, C. Celeste DEd, RN; Joseph, K. S. PhD, MD; Feeley, Nancy PhD, RN†,§; Chambers, Christine T. PhD; Barrington, Keith J. MD; Walker, Claire-Dominique PhD#

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Objective: To examine the effect of co-bedding between preterm twins on stress response after heel lance.

Methods: Using a multisite randomized controlled trial design, stable preterm twins (67 sets, N=134 infants) between 28 and 36 completed weeks’ gestational age, stratified by gestational age (≤ and >32 weeks) and site, were randomly assigned to a co-bedding group, cared for continuously in the same incubator or crib or a standard care group, cared for in a separate incubator or crib, and underwent a medically indicated heel lance after at least 24 hours and no greater than 10 days of group allocation. The reported outcome was cortisol from saliva samples from 89 twins (n=49 co-bedding, n=40 standard care) collected immediately before the heel lance (baseline levels) and 113 twins (n=58 co-bedding, n=55 standard care) collected 20 minutes after heel lance (stress levels) as an index of stress response.

Results: No group differences were noted in baseline salivary cortisol levels: 0.36 μg/dL (SD 0.25) in the co-bedding group and 0.43 μg/dL (SD 0.50) in the standard care group. Twenty minutes after lance, levels were significantly lower in the co-bedding group, 0.28 μg/dL (SD 0.25) versus 0.50 μg/dL (SD 0.73) in the standard group (P=0.04). Similarly, the mean of paired changes in salivary cortisol from baseline was lower in the co-bedding group (−0.06 μg/dL) compared with the standard care group (0.14 μg/dL, P<0.05).

Discussion: Co-bedding attenuates the stress response of preterm twins undergoing heel lance.

Trial Registration: Identifier: NCT009176.

© 2014 by Lippincott Williams & Wilkins

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