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Clinical Journal of Pain:
doi: 10.1097/AJP.0b013e318287a358
Original Articles

Catechol-O-Methyltransferase (COMT) Gene Polymorphisms as Risk Factor in Temporomandibular Disorders Patients From Southern Italy

Michelotti, Ambrosina DDS*; Liguori, Rosario MSc; Toriello, Mario MSc; D’Antò, Vincenzo DDS, PhD*; Vitale, Dino MD; Castaldo, Giuseppe MD, PhD; Sacchetti, Lucia MSc, PhD

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Objectives: To evaluate the role of COMT gene variants as potential risk factors in a group of patients affected with chronic temporomandibular disorder (TMD) pain.

Methods: We sequenced COMT gene in 182 Italian subjects (50 affected by TMD and 132 controls). The study population consisted of patients affected by myogenous and/or arthrogenous pain (RDC/TMD: Ia, Ib, IIIa, IIIb diagnostic categories).

Results: We detected 40 single nucleotide polymorphisms (SNPs) variants (18 novel). Three SNPs, all located in the promoter regions, were more frequently present in cases than in controls (rs 4646310 P=0.018, rs165656 P=0.001, rs 165722 P=0.007). After the False Discovery Rate (FDR) correction rs165656 remained significantly associated with TMD (P=0.049). In addition, the rs 4646310 (AG vs GG, P=0.015) and rs 165656 (GG vs CC, P=0.001) were at binary logistic regression analysis independently associated with TMD, conferring a risk disease of 2.6 (CI= 1.2-5.6) and of 5.3 (CI= 2.0-13.7) respectively.

Discussion: Our data extend the number of SNPs present in the promoter region that could play a regulatory role in COMT gene and suggest that the genetic polymorphisms rs 165656 and rs 4646310 exert a role in TMD susceptibility.

© 2014 by Lippincott Williams & Wilkins

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