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Favorable Outcome of an Acute Complex Regional Pain Syndrome With Immunoglobulin Infusions

Medlin, Friedrich MD; Zekeridou, Anastasia MD; Renaud, Susanne MD; Kuntzer, Thierry MD

Clinical Journal of Pain:
doi: 10.1097/AJP.0b013e318292189e
Online Articles: Case Reports

Objective: To emphasize that complex regional pain syndrome (CRPS), a disabling disorder with the implication of aberrant inflammation, vasomotor dysfunction, and maladaptive neuroplasticity, might be treated with a high dose of intravenous immunoglobulin infusions (IVIG).

Methods: We describe a patient who presented with CRPS in the acute phase of the disease.

Results: The CRPS developed secondary to sciatic compression in a young patient and was treated within 10 days by high-dose IVIG (2 g/kg). It resolved completely within days after infusions.

Discussion: This observational study emphasizes that high-dose IVIG may be a treatment option in the acute phase of CRPS.

Author Information

Nerve-Muscle Unit, Department of Clinical Neurosciences, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland

The authors declare no conflict of interest.

Reprints: Thierry Kuntzer, MD, Service de neurologie, CHUV bh7, rue du Bugnon 47, 1011 Lausanne, Switzerland (e-mail:

Received September 14, 2012

Accepted March 10, 2013

© 2013 by Lippincott Williams & Wilkins