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Progesterone

MAGGIO, LINDSAY MD; ROUSE, DWIGHT J. MD

Clinical Obstetrics & Gynecology: September 2014 - Volume 57 - Issue 3 - p 547–556
doi: 10.1097/GRF.0000000000000039
Prevention of Preterm Birth in 2014

Progestogens are a promising treatment in the prevention of spontaneous preterm birth in high-risk women. In women with a prior history of spontaneous preterm delivery and in women with a sonographic shortened cervix, there is considerable evidence supporting a benefit of progestogen therapy in the reduction of preterm delivery. In women with multifetal gestations, progestogen therapy has not been shown to be beneficial. Data are inconclusive in women with arrested preterm labor. Questions remain about the mechanism of progestogen action, the optimal type of progestogen, the best mode of administration, and the ideal dosing regimen.

Department of Obstetrics and Gynecology, Division of Maternal-Fetal Medicine, Warren Alpert School of Medicine, Brown University, Women and Infants Hospital, Providence, Rhode Island

The authors declare that they have nothing to disclose.

Correspondence: Lindsay Maggio, MD, Department of Obstetrics and Gynecology, Division of Maternal-Fetal Medicine, Warren Alpert School of Medicine, Brown University, Women and Infants Hospital, Providence, RI. E-mail: lmaggio@wihri.org

© 2014 by Lippincott Williams & Wilkins.