Medical Management of Obesity: A Comprehensive ReviewGRUNVALD, EDUARDO MDClinical Obstetrics and Gynecology: September 2014 - Volume 57 - Issue 3 - p 465–484 doi: 10.1097/GRF.0000000000000041 Contemporary Obesity and Lifestyle Issues in Women Abstract Author Information Obesity has reached epidemic proportions, accounting for increased morbidity, disability, health care expenditures, and mortality. Certain metabolic and comorbid conditions disproportionately affect women. Unfortunately, nonsurgical options for treatment are limited. Knowledge accrued over the past 2 decades regarding physiological and hormonal determinants of weight regulation has contributed to growing evidence regarding efficacious behavioral, dietary, and pharmacologic treatments. In this review, the biology of excess adiposity is summarized in the context of a shifting paradigm, approaching obesity as a chronic metabolic disease. Relevant updates are discussed regarding long-term lifestyle approaches and novel drug therapies, with attention to some issues specific to women. Weight Management Program, Bariatric and Metabolic Institute, University of California, San Diego, California The author declares that there is nothing to disclose. Correspondence: Eduardo Grunvald, MD, Weight Management Program, Bariatric and Metabolic Institute, UCSD, 4520 Executive Drive, Suite 111, San Diego, CA 92121. E-mail: email@example.com © 2014 by Lippincott Williams & Wilkins.