Skip Navigation LinksHome > September 2013 - Volume 56 - Issue 3 > The Obstetric Origins of Health for a Lifetime
Clinical Obstetrics & Gynecology:
doi: 10.1097/GRF.0b013e31829cb9ca
Fetal Origins of Adult Disease

The Obstetric Origins of Health for a Lifetime

BARKER, DAVID J.P. MD, PhD*; THORNBURG, KENT L. PhD

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Abstract

There is a new “developmental” model for the origins of a wide range of chronic diseases. Under this model the causes to be identified are linked to normal variations in fetoplacental development. These variations are thought to lead to variations in the supply of nutrients to the baby that permanently alter gene expression, a process known as “programming.” According to the developmental model variations in the processes of development program the function of a few key systems that are linked to disease, including the immune system, antioxidant defenses, inflammatory responses, and the number and quality of stem cells.

© 2013, Lippincott Williams & Wilkins

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