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Programming of Osteoporosis and Impact on Osteoporosis Risk

DENNISON, ELAINE M. PhD*; HARVEY, NICHOLAS C. PhD*; COOPER, CYRUS FmedSci*,†

Clinical Obstetrics and Gynecology: September 2013 - Volume 56 - Issue 3 - p 549–555
doi: 10.1097/GRF.0b013e31829cb9b0
Fetal Origins of Adult Disease

Osteoporosis is a skeletal disorder characterized by reduced bone quantity and quality and an increased susceptibility to fracture, and seems to be one of many chronic conditions that might be influenced by events early in life. Specifically, there is growing evidence of an interaction between the genome and the environment in the expression of the disease.

*MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton General Hospital, Southampton

NIHR Musculoskeletal Biomedical Research Unit, University of Oxford, Oxford, UK

C.C. has received consulting and lecture fees from AMGEN, GSK, Alliance for Better Bone Health, MSD, Eli Lilly, Pfizer, Novartis, Servier, Medtronic, and Roche. The remaining authors declare that they have nothing to disclose.

Correspondence: Elaine M. Dennison, PhD, MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton General Hospital, Southampton, SO16 6YD, UK. E-mail: emd@mrc.soton.ac.uk

© 2013 by Lippincott Williams & Wilkins.