Osteoporosis is a skeletal disorder characterized by reduced bone quantity and quality and an increased susceptibility to fracture, and seems to be one of many chronic conditions that might be influenced by events early in life. Specifically, there is growing evidence of an interaction between the genome and the environment in the expression of the disease.
*MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton General Hospital, Southampton
†NIHR Musculoskeletal Biomedical Research Unit, University of Oxford, Oxford, UK
C.C. has received consulting and lecture fees from AMGEN, GSK, Alliance for Better Bone Health, MSD, Eli Lilly, Pfizer, Novartis, Servier, Medtronic, and Roche. The remaining authors declare that they have nothing to disclose.
Correspondence: Elaine M. Dennison, PhD, MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton General Hospital, Southampton, SO16 6YD, UK. E-mail: firstname.lastname@example.org