Skip Navigation LinksHome > September 2013 - Volume 56 - Issue 3 > Prenatal Programming of Insulin Secretion in Intrauterine Gr...
Clinical Obstetrics & Gynecology:
doi: 10.1097/GRF.0b013e31829e5b29
Fetal Origins of Adult Disease

Prenatal Programming of Insulin Secretion in Intrauterine Growth Restriction

GATFORD, KATHRYN L. PhD*; SIMMONS, REBECCA A. MD

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Abstract

Intrauterine growth restriction (IUGR) impairs insulin secretion in humans and in animal models of IUGR. Several underlying mechanisms have been implicated, including decreased expression of molecular regulators of β-cell mass and function, in some cases shown to be due to epigenetic changes initiated by an adverse fetal environment. Alterations in cell cycle progression contribute to loss of β-cell mass, whereas decreased islet vascularity and mitochondrial dysfunction impair β-cell function in IUGR rodents. Animal models of IUGR sharing similar insulin secretion outcomes as the IUGR human are allowing underlying mechanisms to be identified. This review will focus on models of uteroplacental insufficiency.

© 2013, Lippincott Williams & Wilkins

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