Skip Navigation LinksHome > June 2013 - Volume 56 - Issue 2 > Pharmacology and Pharmacogenomics of Neurological Medication...
Clinical Obstetrics & Gynecology:
doi: 10.1097/GRF.0b013e31828f241d
Neurologic Diseases in Pregnancy: An Overview

Pharmacology and Pharmacogenomics of Neurological Medications Used in Pregnancy

CAMPBELL, SARAH C. PhD; SPIGARELLI, MICHAEL G. MD, PhD

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Abstract

Pregnancy increases the pharmacological management challenge of numerous neurological diseases as a result of complex physiological changes. Understanding pregnancy-induced changes in pharmacokinetic and pharmacodynamic parameters can lead to better outcomes for both the mother and baby. Although the application of pharmacogenomics in maternal-fetal medicine is in its infancy, further research and developments will provide important new developments for managing the efficacy of drug treatments during pregnancy and improving maternal-fetal safety. Although a wide variety of neurological medications are used during pregnancy, this article will focus on the drugs with currently known pharmacogenomic implications.

© 2013 by Lippincott Williams & Wilkins.

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