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Epilepsy in Pregnancy

KAMYAR, MANIJEH MD; VARNER, MICHAEL MD

Clinical Obstetrics & Gynecology: June 2013 - Volume 56 - Issue 2 - p 330–341
doi: 10.1097/GRF.0b013e31828f2436
Neurologic Diseases in Pregnancy: An Overview

Over 25,000 epileptic women deliver viable pregnancies each year in the United States. Although medical management is the first line of treatment, many physiological changes associated with pregnancy can make optimal treatment challenging. Medication dosage is adjusted based on side effects and seizure frequency, with the goal being no seizures with the lowest medication dosage(s) and side-effect profile possible. Whenever possible, monotherapy is preferred. Many antiepileptic drugs have teratogenic potential, so preconceptional optimization of medication dosage(s) is recommended. Epilepsy has associated neurological comorbidities, the most common being migraines and sleep disorders.

Department of Obstetrics and Gynecology, University of Utah Health Sciences Center, Salt Lake City, Utah

The authors declare that they have nothing to disclose.

Correspondence: Manijeh Kamyar, MD, Department of Obstetrics and Gynecology, University of Utah Health Sciences Center, Salt Lake City, UT. E-mail: manijeh.kamyar@hsc.utah.edu

© 2013 by Lippincott Williams & Wilkins.