Influenza infection during pregnancy imparts disproportionate morbidity and mortality. This has been primarily noted during occasional influenza pandemics but also during seasonal epidemics. The majority of pregnant women who contract influenza appear to have a mild, self-limited course. However, influenza produces a severe life-threatening respiratory illness among a non-negligible and partially unpredictable portion of susceptible pregnant women. Influenza vaccination is the most effective way to prevent this occasionally fatal infection and is recommended for all pregnant women lacking contraindication. Antiviral medications are indicated for both prophylaxis and treatment for suspected and/or confirmed influenza infection during pregnancy.