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Serum Biomarkers for Detecting Ectopic Pregnancy

RAUSCH, MARY E. MD, MSCE*; BARNHART, KURT T. MD, MSCE

Clinical Obstetrics & Gynecology:
doi: 10.1097/GRF.0b013e31825109f6
Ectopic Pregnancy
Abstract

Unless an ectopic pregnancy is visible by ultrasound, diagnosis can be a challenge. Differentiating ectopic pregnancies from intrauterine pregnancies can be impossible without intervention or follow-up. This poses a clinical dilemma to the practitioner given the inherent danger to the mother of tubal rupture of an ectopic pregnancy versus the fear of intervening in the case of a desired pregnancy without certainty of diagnosis. Early diagnostic modalities are clearly lacking, and serum biomarkers are currently being investigated as a solution to need for a rapid and accurate test for ectopic pregnancy.

Author Information

*Department of Obstetrics and Gynecology, Center for Human Reproduction, North Shore University Hospital, Manhasset, New York;

Department of Obstetrics and Gynecology, Penn Fertility Care, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania

Supported by NIH grants K24HD060687(KB)and R01-HD036455 (KB).

The authors declare that they have nothing to disclose.

Correspondence: Mary E. Rausch, MD, MSCE, Department of Obstetrics and Gynecology, Center for Human Reproduction, North Shore University Hospital, Manhasset, NY. E-mail: mrausch@nshs.edu

© 2012 Lippincott Williams & Wilkins, Inc.