Unless an ectopic pregnancy is visible by ultrasound, diagnosis can be a challenge. Differentiating ectopic pregnancies from intrauterine pregnancies can be impossible without intervention or follow-up. This poses a clinical dilemma to the practitioner given the inherent danger to the mother of tubal rupture of an ectopic pregnancy versus the fear of intervening in the case of a desired pregnancy without certainty of diagnosis. Early diagnostic modalities are clearly lacking, and serum biomarkers are currently being investigated as a solution to need for a rapid and accurate test for ectopic pregnancy.
*Department of Obstetrics and Gynecology, Center for Human Reproduction, North Shore University Hospital, Manhasset, New York;
†Department of Obstetrics and Gynecology, Penn Fertility Care, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania
Supported by NIH grants K24HD060687(KB)and R01-HD036455 (KB).
The authors declare that they have nothing to disclose.
Correspondence: Mary E. Rausch, MD, MSCE, Department of Obstetrics and Gynecology, Center for Human Reproduction, North Shore University Hospital, Manhasset, NY. E-mail: firstname.lastname@example.org