Skip Navigation LinksHome > June 2012 - Volume 55 - Issue 2 > Methotrexate: The Pharmacology Behind Medical Treatment for...
Clinical Obstetrics & Gynecology:
doi: 10.1097/GRF.0b013e3182510a35
Ectopic Pregnancy

Methotrexate: The Pharmacology Behind Medical Treatment for Ectopic Pregnancy

STIKA, CATHERINE S. MD

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Abstract

Previously established as a chemotherapeutic agent for decades, methotrexate has been adapted for use as a medical therapy for unruptured ectopic pregnancies. Its mechanism of action, competitive inhibition of folate-dependent steps in nucleic acid synthesis, effectively kills the rapidly dividing ectopic trophoblast. However, the same action on normal cells is the basis for many of its adverse effects.

© 2012 Lippincott Williams & Wilkins, Inc.

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