Measles, mumps, and rubella are viral diseases that may adversely affect nonimmune pregnant women and their fetuses/neonates. Prevention of these diseases and their complications can be achieved through measles-mumps-rubella (MMR) vaccination before pregnancy. The vaccine is contraindicated during pregnancy, because it contains live, attenuated viruses that pose a theoretical risk to the fetus. However, accidental receipt of MMR vaccination is not known to cause maternal/fetal complications. MMR immunization is recommended to nonimmune obstetric patients upon completion or termination of pregnancy.
*Mayo Clinic Vaccine Research Group
†Program in Translational Immunovirology and Biodefense
Departments of ‡Obstetrics and Gynecology
∥Pediatric and Adolescent Medicine;
§Mayo Graduate School, Mayo Clinic, Rochester, Minnesota.
Supported by National Institute of Health grants R01 AI33144-15, R01 AI48973-11, and UL1 RR024150-01.
G.A.P. chairs data monitoring committees for nonmeasles vaccines being developed by Merck & Co. R.M.J. also serves on a data monitoring committee and a safety review committee concerning nonmeasles vaccines produced by Merck & Co. The remaining authors declare that they have nothing to disclose.
Correspondence: Robert M. Jacobson, MD, Mayo Clinic Desk Ba3b, Rochester, MN. E-mail: Jacobson.Robert@mayo.edu