Skip Navigation LinksHome > March 2012 - Volume 55 - Issue 1 > Molecular/Genetic Therapies in Ovarian Cancer: Future Oppor...
Clinical Obstetrics & Gynecology:
doi: 10.1097/GRF.0b013e31824b1699
Ovarian Cancer

Molecular/Genetic Therapies in Ovarian Cancer: Future Opportunities and Challenges

ZIEBARTH, ANGELA J. MD; LANDEN, CHARLES N. Jr MD; ALVAREZ, RONALD D. MD

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Abstract

Ovarian cancer is the most lethal gynecologic cancer. Traditional therapies have included surgical management and cytotoxic chemotherapy; however, treatment paradigms continue to shift from empiric cytotoxic chemotherapy to more individualized treatment. Recent research efforts have focused on determining and targeting the molecular biological mechanisms of ovarian cancer in an attempt to develop novel therapeutic modalities with the ultimate goal of improving outcome while limiting toxicity. This chapter reviews progress in the development of novel therapies directed at major pathways implicated in ovarian tumorigenesis including angiogenesis, PARP inhibition, signal transduction, antifolate therapies, death receptor-mediated therapies, histone deacetylase inhibition, immunotherapeutics, and oncolytics.

© 2012 Lippincott Williams & Wilkins, Inc.

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