Diminished Ovarian Reserve and InfertilityGURTCHEFF, SHAWN E. MD; KLEIN, NANCY A. MDClinical Obstetrics & Gynecology: December 2011 - Volume 54 - Issue 4 - p 666–674 doi: 10.1097/GRF.0b013e3182353c65 Infertility Abstract Author Information Abstract Over the past several decades, social and demographic trends have led to an increased tendency for women to delay childbearing. Owing primarily to abnormalities in the oocyte and resulting embryonic aneuploidy, implantation, clinical pregnancy, and live birth rates decline sharply by the end of the fourth decade. As a result, the incidence of age-related infertility has increased. Improved awareness of the effects of aging on fertility combined with ovarian reserve assessment, patient education, and early infertility evaluation and intervention are important elements in appropriate family planning and prevention of age-related infertility. Author Information Seattle Reproductive Medicine, Seattle, Washington The authors declare that they have nothing to disclose. Correspondence: Nancy A. Klein, MD, 1505 Westlake Avenue N., Suite 400, Seattle, WA 98105. E-mail: email@example.com © 2011 Lippincott Williams & Wilkins, Inc.