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Overt Hyperthyroidism and Hypothyroidism During Pregnancy

STAGNARO-GREEN, ALEX MD, MHPE

Clinical Obstetrics & Gynecology: September 2011 - Volume 54 - Issue 3 - p 478–487
doi: 10.1097/GRF.0b013e3182272f32
Thyroid Disease in Pregnancy

The present manuscript provides a definition for, and evaluates the prevalence and maternal/fetal/child impact of, overt hyperthyroidism and overt hypothyroidism. The prevalence of overt hyperthyroidism is 0.5% and the prevalence of overt hyperthyroidism is 0.3%. Overt maternal hyperthyroidism is associated with heart failure, preeclampsia, preterm delivery, still birth, and neonatal mortality. Overt maternal hypothyroidism is associated with preeclampsia, gestational hypertension, cretinism, fetal deaths, and spontaneous abortion. A cost-effective analysis for screening and treating overt thyroid disease during pregnancy is warranted.

George Washington University School of Medicine and Health Sciences, Washington, DC

There were no sources of financial support for this manuscript.The author has no conflicts of interest.

Correspondence: Alex Stagnaro-Green, MD, MHPE, George Washington University School of Medicine and Health Sciences, 2300 Eye Street, Ross Hall, Suite 712, Washington, DC. E-mail: msdasg@gwumc.edu.

© 2011 Lippincott Williams & Wilkins, Inc.