Uterine Papillary Serous CarcinomaMOORE, KATHLEEN N. MD*; NICKLES FADER, AMANDA MD†Clinical Obstetrics & Gynecology: June 2011 - Volume 54 - Issue 2 - p 278–291 doi: 10.1097/GRF.0b013e318218c755 Endometrial Cancer Abstract Author Information Uterine papillary serous carcinoma (UPSC) is a histologic variant of endometrial cancer that accounts for only 10% of new cases of uterine cancer but is responsible for 40% of deaths from the disease. UPSC is an aggressive tumor with a predilection for early spread beyond the uterus. Treatment for UPSC typically entails surgery and in most women is followed by multimodality adjuvant therapy. In this review, we describe the epidemiology, natural history, treatment, and outcome of UPSC. *Department of Gynecologic Oncology, University of Oklahoma, Oklahoma City, Oklahoma †Greater Baltimore Medical Center, Baltimore, Maryland Correspondence: Kathleen N. Moore, MD, Gynecologic Oncology, University of Oklahoma, 920 SL Young Boulevard, Oklahoma City, OK. e-mail: firstname.lastname@example.org © 2011 Lippincott Williams & Wilkins, Inc.