Lynch SyndromeBACKES, FLOOR J. MD; COHN, DAVID E. MDClinical Obstetrics & Gynecology: June 2011 - Volume 54 - Issue 2 - p 199–214 doi: 10.1097/GRF.0b013e3182185a41 Endometrial Cancer Abstract Author Information Almost 100 years ago Lynch syndrome was discovered by Dr Aldred Warthin. Initially, the syndrome was named Hereditary Nonpolyposis Colorectal Cancer as colorectal cancer seemed most prevalent. Over time uterine cancer and several other malignancies were recognized as part of the spectrum. This autosomal-dominant inherited cancer syndrome is characterized by a defect in mismatch repair genes and puts patients at a significantly increased risk for colorectal and uterine cancer. Recognition and diagnosis of Lynch syndrome is extremely important so that appropriate screening programs and/or risk-reducing surgery can be initiated to prevent development or promote early detection of cancers. Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, The Ohio State University College of Medicine, Columbus, Ohio Correspondence: David E. Cohn, MD, Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, The Ohio State University College of Medicine, M210 Starling Loving Hall, 320 West 10th Avenue, Columbus, OH 43204. e-mail: firstname.lastname@example.org © 2011 Lippincott Williams & Wilkins, Inc.