Herpes Simplex and HIV Infections and Preterm PROMEHSANIPOOR, ROBERT M. MD*; MAJOR, CAROL A. MD†Clinical Obstetrics & Gynecology: June 2011 - Volume 54 - Issue 2 - p 330–336 doi: 10.1097/GRF.0b013e318217d7a6 Preterm Premature Rupture Of The Membranes Abstract Author Information Abstract Maternal human immunodeficiency virus (HIV) and genital herpes simplex virus (HSV) infection in pregnancy have potential for vertical transmission that may result in death or morbidity. The risk increases with preterm delivery and prolonged ruptured membranes. When managing preterm premature rupture of membranes, the risk of transmission must be weighed against the risk of prematurity. Before 32 to 34 weeks, expectant management is preferred for patients with well controlled HIV or recurrent active genital HSV infection. For patients with advanced HIV disease or primary genital HSV infection, the risk of vertical transmission is higher and many clinical factors need to be considered. Author Information *Johns Hopkins University, Baltimore, Maryland †University of California, Irvine, Orange, California Correspondence: Robert M. Ehsanipoor, MD, Johns Hopkins University, Phipps 228, Baltimore, MD. e-mail: email@example.com. © 2011 Lippincott Williams & Wilkins, Inc.