Considerations in Membrane Resealing After Preterm PROMJAIN, VANITA DHARAN MD; SCISCIONE, ANTHONY MDClinical Obstetrics and Gynecology: June 2011 - Volume 54 - Issue 2 - p 351–357 doi: 10.1097/GRF.0b013e318217edaf Preterm Premature Rupture Of The Membranes Abstract Author Information Current management of preterm premature rupture of the membranes centers around the expectant management with antibiotics and steroid therapy. Membrane rupture seems to be the result of a mechanical event. Studying the physical properties of the membranes may help to gain understanding of the nature and causes of membrane rupture. This article reviews membrane mechanics, advances in membrane healing, and strategies in the prevention of membrane rupture. The physiologic mechanisms that lead to membrane rupture have not yet been fully elucidated. Models that test the biomechanics of the membranes should be used to develop strategies for repair or prevention. Division of Maternal Fetal Medicine, Department of Obstetrics & Gynecology, Delaware Center for Maternal Fetal Medicine, Christiana Hospital, Newark, Delaware Sources of Support: None. Correspondence: Anthony Sciscione, MD, Division of Maternal Fetal Medicine, Department of Obstetrics & Gynecology, Delaware Center for Maternal Fetal Medicine, Christiana Hospital, Suite 1992, Newark, DE. e-mail: email@example.com © 2011 Lippincott Williams & Wilkins, Inc.