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Considerations in Membrane Resealing After Preterm PROM

JAIN, VANITA DHARAN MD; SCISCIONE, ANTHONY MD

Clinical Obstetrics & Gynecology:
doi: 10.1097/GRF.0b013e318217edaf
Preterm Premature Rupture Of The Membranes
Abstract

Current management of preterm premature rupture of the membranes centers around the expectant management with antibiotics and steroid therapy. Membrane rupture seems to be the result of a mechanical event. Studying the physical properties of the membranes may help to gain understanding of the nature and causes of membrane rupture. This article reviews membrane mechanics, advances in membrane healing, and strategies in the prevention of membrane rupture. The physiologic mechanisms that lead to membrane rupture have not yet been fully elucidated. Models that test the biomechanics of the membranes should be used to develop strategies for repair or prevention.

Author Information

Division of Maternal Fetal Medicine, Department of Obstetrics & Gynecology, Delaware Center for Maternal Fetal Medicine, Christiana Hospital, Newark, Delaware

Sources of Support: None.

Correspondence: Anthony Sciscione, MD, Division of Maternal Fetal Medicine, Department of Obstetrics & Gynecology, Delaware Center for Maternal Fetal Medicine, Christiana Hospital, Suite 1992, Newark, DE. e-mail: asciscione@christianacare.org

© 2011 Lippincott Williams & Wilkins, Inc.