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Antenatal Corticosteroids After Preterm Premature Rupture of Membranes

VIDAEFF, ALEX C. MD, MPH; RAMIN, SUSAN M. MD

Clinical Obstetrics & Gynecology:
doi: 10.1097/GRF.0b013e318217d85b
Preterm Premature Rupture Of The Membranes
Abstract

Preterm premature rupture of membranes (PPROM) is an obstetrical complication associated with high neonatal morbidity and mortality. The current management of PPROM focuses on neonatal benefit and includes the ancillary use of corticosteroids for fetal maturation. The purpose of this work was to provide a comprehensive and unbiased review of the available literature on prenatal administration of corticosteroids in conditions of PPROM, and to address the rationale and the relevant supporting evidence for this practice. We conclude that the cumulative level I evidence indicates a definite beneficial effect of corticosteroids in conditions of PPROM.

Author Information

Division of Maternal-Fetal Medicine, Department of Obstetrics, Gynecology and Reproductive Sciences, University of Texas Health Science Center at Houston, Houston, Texas

Correspondence: Alex C. Vidaeff, MD, MPH, Department of Obstetrics, Gynecology and Reproductive Sciences, 6431 Fannin, Suite 3.283, Houston, TX. e-mail: alex.c.vidaeff@uth.tmc.edu

© 2011 Lippincott Williams & Wilkins, Inc.