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Whole Ovary Transplantation

BEDAIWY, MOHAMED A. MD, PHD*; FALCONE, TOMMASO MD

Clinical Obstetrics and Gynecology: December 2010 - Volume 53 - Issue 4 - p 797-803
doi: 10.1097/GRF.0b013e3181f97c94
Fertility Preservation: New Developments

Several strategies have been developed in an attempt to preserve fertility in these women, including ovarian transplantation. The current protocols of ovarian transplantation require transplanting fresh or cryopreserved-thawed ovarian cortical strips in an orthotopic or heterotopic location. The main limitation of this approach is the limited longevity of graft function because of the posttransplantation ischemic injury. Whole ovary cryopreservation with its' vascular pedicle with subsequent transplantation with a vascular anastomosis is one experimental approach to minimize the effects of ischemic damage including whole ovary transplantation.

*Department of Obstetrics-Gynecology, University Hospitals Case Medical Center, Case Western Reserve University

Department of Obstetrics-Gynecology, The Cleveland Clinic Foundation, Cleveland, Ohio

Correspondence: Tommaso Falcone, MD, FRCSC, FACOG, Department of Obstetrics-Gynecology and Women's Health Institute, A81, Cleveland, OH. E-mail: falcont@ccf.org

© 2010 Lippincott Williams & Wilkins, Inc.