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Toxicity of Chemotherapy and Radiation on Female Reproduction

MEIROW, DROR MD*; BIEDERMAN, HANNAH BSc*; ANDERSON, RICHARD A. MD; WALLACE, W. HAMISH B. MD

Clinical Obstetrics & Gynecology: December 2010 - Volume 53 - Issue 4 - pp 727-739
doi: 10.1097/GRF.0b013e3181f96b54
Fertility Preservation: New Developments

One of the most devastating consequences of cancer treatment in the young female population is ovarian damage, resulting in diminished fertility potential. The extent of damage is related to age, chemotherapeutic regimen, and dose of pelvic radiation received. It is crucial that physicians know the impact each of these factors has on future fertility to advice patients on fertility preservation options. Anticancer drugs injure the female reproductive system through ovarian follicular and stromal damage. Although the exact mechanisms of damage remain unclear, it is essential to better understand these mechanisms to develop methods to diminish ovarian injury.

*Division of Obstetrics and Gynecology, IVF Unit, Fertility Preservation Laboratory, Sheba Medical Center, Tel-Aviv University, Israel

Division of Reproductive and Developmental Science, University of Edinburgh, Edinburgh, United Kingdom

Correspondence: Dror Meirow, MD, Division of Obstetrics and Gynecology, IVF Unit, Sheba Medical Center, Tel Hashomer, Israel. E-mail: meirow@post.tau.ac.il

© 2010 Lippincott Williams & Wilkins, Inc.