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Indications and Strategies for Fertility Preservation in Men

STAHL, PETER J. MD; STEMBER, DORON S. MD; HSIAO, WAYLAND MD; SCHLEGEL, PETER N. MD

Clinical Obstetrics & Gynecology: December 2010 - Volume 53 - Issue 4 - pp 815-827
doi: 10.1097/GRF.0b013e3181f980b3
Fertility Preservation: New Developments

Fertility preservation is feasible in the majority of men. Herein, we review the reproductive toxicities of commonly encountered clinical threats to male fertility, including cancer, radiotherapy, chemotherapy, surgery, and nonmalignant diseases treated with immunosuppression. Other scenarios, in which fertility preservation may be considered, such as Klinefelter syndrome, acute testicular injury, and sudden unexpected death, are also discussed. We provide an algorithmic approach to fertility preservation in men, and review strategies for sperm acquisition in cases of ejaculatory dysfunction and azoospermia. Lastly, emerging options for fertility preservation in prepubertal boys are discussed.

James Buchanan Brady Department of Urology, Weill Cornell Medical College, New York, New York

Funding: None.

Correspondence: Peter J. Stahl, MD, 435 East 70th Street #28D, New York, NY 10021. E-mail: pjs2002@med.cornell.edu

© 2010 Lippincott Williams & Wilkins, Inc.