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Cryopreservation and Transplantation of Ovarian Tissue

DONNEZ, JACQUES MD, PhD; DOLMANS, MARIE-MADELEINE MD, PhD

Clinical Obstetrics & Gynecology: December 2010 - Volume 53 - Issue 4 - pp 787-796
doi: 10.1097/GRF.0b013e3181f97a55
Fertility Preservation: New Developments

Cryopreservation and autotransplantation of ovarian tissue for fertility preservation is considered an experimental technique. However, in some clinical situations it remains the only option. Eleven pregnancies have been reported worldwide from this procedure. Transplantation of ovarian tissue pieces without a vascular pedicle requires the establishment of a new blood supply that takes 5 days. This leads to a substantial loss of follicles in the graft that may limit the longevity of the graft.

Department of Gynecology, Université Catholique de Louvain, Brussels, Belgium

Correspondence: Jacques Donnez, MD, PhD, Department of Gynecology, Université Catholique de Louvain, Cliniques Universitaires St Luc, Brussels, Belgium. E-mail: jacques.donnez@uclouvain.be

© 2010 Lippincott Williams & Wilkins, Inc.