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Thrombophilias and Stillbirth

WERNER, ERIKA F. MD; LOCKWOOD, CHARLES J. MD, MHCM

Clinical Obstetrics & Gynecology: September 2010 - Volume 53 - Issue 3 - pp 617-627
doi: 10.1097/GRF.0b013e3181eb658c
Stillbirth

It is often postulated that both inherited and acquired thrombophilias increase the risk of stillbirth. In an attempt to reduce this theoretical risk, pregnant patients with prior fetal losses and thrombophilias are anticoagulated. However, there is no definitive proof that thrombophilias are causally linked to stillbirth. Prospective studies have failed to establish a definitive link between inherited thrombophilias and stillbirth. The extant literature suggests that only high concentrations of antiphospholipid antibodies are associated with stillbirth. Moreover, when pregnant women with prior fetal losses even in these cases are placed on anticoagulation, it is unclear that their recurrence risk of stillbirth decreases.

Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut

Correspondence: Erika F. Werner, MD, Section of Maternal Fetal Medicine, Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, PO Box 208063, New Haven, CT. E-mail: erika.werner@yale.edu

© 2010 Lippincott Williams & Wilkins, Inc.