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Infectious Causes of Stillbirth: A Clinical Perspective

MCCLURE, ELIZABETH M. MEd*; DUDLEY, DONALD J. MD; REDDY, UMA M. MD; GOLDENBERG, ROBERT L. MD§

Clinical Obstetrics and Gynecology: September 2010 - Volume 53 - Issue 3 - p 635-645
doi: 10.1097/GRF.0b013e3181eb6620
Stillbirth

Untreated infection may cause stillbirth by several mechanisms, including direct fetal infection, placental damage, and severe maternal illness. Many bacteria, viruses, and protozoa have been associated with stillbirth. In developed countries, up to 24% of stillbirths have been attributed to infection, although with increased availability of sophisticated diagnostics and rigorous screening, it appears likely that higher numbers may actually be associated with infection. In developed countries, ascending bacterial infection is usually the most common infectious cause of stillbirth, with a number of viral infections also an important factor. Screening, prevention, and treatment of maternal infections are important to reduce stillbirth risk.

*Department of Epidemiology, Global School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina

Department of Obstetrics and Gynecology, University of Texas Health Science Center at San Antonio, San Antonio, Texas

Eunice Kennedy Shriver National Institute of Child Health and Human Development, Rockville, Maryland

§Department of Obstetrics/Gynecology, Drexel University College of Medicine, Philadelphia, Pennsylvania

Correspondence: Robert L. Goldenberg, MD, Department of Obstetrics/Gynecology, Drexel University College of Medicine, 245 N. 15th Street, 17th Floor, Room 17113, Philadelphia, PA 19102. E-mail: rgoldenb@drexelmed.edu

© 2010 Lippincott Williams & Wilkins, Inc.