Skip Navigation LinksHome > September 2008 - Volume 51 - Issue 3 > Once-daily Dosing of Gentamicin in Obstetrics and Gynecology
Clinical Obstetrics & Gynecology:
doi: 10.1097/GRF.0b013e31818091cd
New Antibiotics and Vaccines in Obstetric Practice

Once-daily Dosing of Gentamicin in Obstetrics and Gynecology

WARD, KRISTY MD; THEILER, REGAN N. MD, PhD

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Abstract

Gentamicin, an aminoglycoside with broad antimicrobial activity, is commonly used in both obstetrics and gynecology. Traditional dosing regimens for gentamicin have called for 3 times daily dosing, but recent insights into the pharmacodynamics of the drug have led to multiple studies of once-daily dosing regimens. Many studies have demonstrated efficacy, safety, and economy of the 24-hour dosing interval, resulting in recommendations that this become the standard for aminoglycoside administration. However, because of the unique considerations for drug administration in pregnant and postpartum women, the once-daily dosing regimens have not been widely adopted. Additional studies in pregnant and postpartum women have demonstrated therapeutic noninferiority, no increase in adverse events, and significant cost savings with once-daily dosing versus 3 times daily dosing of gentamicin. We review the literature and present rationale based on multiple controlled studies supporting single-daily dosing of gentamicin, 5 mg/kg/d actual body weight, for many common obstetrics-gynecology infections.

© 2008 Lippincott Williams & Wilkins, Inc.

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