You could be reading the full-text of this article now if you...

If you have access to this article through your institution,
you can view this article in

The Use of Nuchal Translucency in Contemporary Obstetric Practice

SAID, SOHA MRCOG, MRCPI; MALONE, FERGAL D. MD

Clinical Obstetrics & Gynecology:
doi: 10.1097/GRF.0b013e318160f2ea
Current Concepts in Prenatal Genetics
Abstract

Nuchal translucency sonography is the most powerful single prenatal marker for Down syndrome. Its detection rate is 75% at a 5% false-positive rate. The combination of nuchal translucency and maternal serum-free β-human chorionic gonadotropin and pregnancy-associated plasma protein-A can identify 85% to 90% of fetuses with Down syndrome for a false-positive rate of 5%. This method can also identify more than 90% of fetuses with trisomies 18 and 13, Turner syndrome, and triploidy for a screen-positive rate of 1%.

Author Information

Department of Obstetrics and Gynecology, Royal College of Surgeons in Ireland (RCSI), Rotunda Hospital, Parnell Square, Dublin 1, Republic of Ireland

Correspondence: Prof Fergal D. Malone, MD, Department of Obstetrics and Gynecology, Royal College of Surgeons in Ireland (RCSI), Rotunda Hospital, Parnell Square, Dublin 1, Republic of Ireland. E-mail: fmalone@rcsi.ie

© 2008 Lippincott Williams & Wilkins, Inc.