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Genetics of Pregnancy Loss

WARREN, JENNIFER E. MD; SILVER, ROBERT M. MD

Clinical Obstetrics & Gynecology: March 2008 - Volume 51 - Issue 1 - pp 84-95
doi: 10.1097/GRF.0b013e318161719c
Current Concepts in Prenatal Genetics

Pregnancy loss is a common problem in reproductive-aged women. Although most cases of pregnancy loss are sporadic, some couples experience recurrent pregnancy loss, a challenging clinical dilemma. A variety of possible etiologies have been described for both sporadic and recurrent pregnancy loss. This review focuses on the genetic abnormalities that may contribute to this clinical problem and delineates strategies for genetic evaluation and clinical management in subsequent pregnancies.

Departments of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, University of Utah, Salt Lake City, Utah

Correspondence: Robert M. Silver, MD, Departments of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, University of Utah, East, Suite 2B200, Salt Lake City, Utah. E-mail: Robert.silver@hsc.utah.edu

© 2008 Lippincott Williams & Wilkins, Inc.